Supplementary MaterialsS1 Fig: Induction of GL transcription and class switching. predominantly methylated at VX-765 enzyme inhibitor CpG dinucleotides. Unmethylated CpGs are often associated with active regulatory sequences while methylated CpGs are often linked to transcriptional silencing. Previous studies on CpG methylation led to the notion that transcription initiation is usually more sensitive to VX-765 enzyme… Continue reading Supplementary MaterialsS1 Fig: Induction of GL transcription and class switching. predominantly