The ubiquitin-like modifier interferon-stimulated gene 15 (ISG15) is implicated in both oncogenic and tumor suppressive programs. destabilize PTEN whereas USP18 overexpression stabilized PTEN proteins. Oddly enough, repression of USP18 reduced cytoplasmic PTEN in accordance with nuclear PTEN proteins amounts. We sought to recognize mechanisms involved in this PTEN proteins destabilization using immunoprecipitation assays and discovered… Continue reading The ubiquitin-like modifier interferon-stimulated gene 15 (ISG15) is implicated in both