The E1 envelope protein from the alphavirus Semliki Forest virus (SFV) is a class II fusion protein that mediates low pH-triggered membrane fusion during virus infection. stem was hidden on neutral pH disease but became accessible after low pH-triggered dissociation of the E2/E1 heterodimer. The stem packed onto the trimer core in the postfusion conformation… Continue reading The E1 envelope protein from the alphavirus Semliki Forest virus (SFV)