The next of three SPRY domains (SPRY2, S1085-V1208) located in the skeletal muscle ryanodine receptor (RyR1) is contained within regions of RyR1 that influence EC coupling and bind to imperatoxin A, a toxin probe of RyR1 channel gating. TMC 278 interact in an F loop regulatory module. Although a region that includes the SPRY2 website… Continue reading The next of three SPRY domains (SPRY2, S1085-V1208) located in the