To check the hypothesis that altered expression of BRCA1 protein may play an important role in sporadic breast cancer development, 50 randomly selected primary breast cancers (frozen sections, 5 years’ median follow-up) were immunolabelled with two monoclonal BRCA1 antibodies (MS110 and MS13). eventual progression to malignancy. germline mutations have been described in only a handful… Continue reading To check the hypothesis that altered expression of BRCA1 protein may