Background Tissue recruitment and activation of eosinophils contribute to allergic symptoms by causing airway hyperresponsiveness and inflammation. factor. Results Eosinophils from wild-type mice displayed inducible superoxide release, but at a small fraction (4C5%) of human eosinophils. Rac2-deficient eosinophils showed significantly less superoxide release (p 0.05, 26% less than wild type). Eosinophils lacking Rac2 had diminished… Continue reading Background Tissue recruitment and activation of eosinophils contribute to allergic symptoms