Supplementary MaterialsSupplementary Figures. Moreover, the GS substrates and PKI-587 enzyme inhibitor glutamine precursors glutamate and ammonia restored proliferation of glutamine-deprived cells in a GS-dependent manner, further emphasizing the necessity of GS for adaptation to glutamine stress. Furthermore, pharmacological and shRNA-mediated GS inhibition significantly reduced orthotopic xenograft tumor growth. We also show that glutamine supports sarcoma… Continue reading Supplementary MaterialsSupplementary Figures. Moreover, the GS substrates and PKI-587 enzyme