Mutations on NHR (N-terminal heptad do it again) associated with resistance to fusion inhibitor were observed. the CHR (C34) located near the hydrophobic groove of the NHR. Because the conformational stability of 6-HB is important to HIV-1 infection, we suggested a hypothetical mechanism for the drug resistance: N43D single mutation not only impact the binding… Continue reading Mutations on NHR (N-terminal heptad do it again) associated with resistance