Purpose. well as by inhibitors of the canonical Smad2, -3, and -4 signaling and non-Smad JNK/AP-1 signaling pathways (< 0.05). Conclusions. Both Smad and non-Smad signaling pathways are involved in TGF-mediated induction, suggesting complex regulation of these important extracellular matrix cross-linking enzymes. Increased LOX activity may be at least partially responsible for TGF-mediated IOP elevation… Continue reading Purpose. well as by inhibitors of the canonical Smad2, -3, and