Supplementary Components1. and FLT3 signaling protein. Significantly, -catenin inhibition abrogated the microenvironmental security afforded the leukemic stem/progenitor cells. Bottom line Disrupting Wnt/-catenin signaling exerts powerful actions against AML stem/progenitor cells and synergizes with FLT3 inhibition in mutations also straight cooperate with Wnt signaling in AML (10). mutations are connected with poor prognosis in AML (11,… Continue reading Supplementary Components1. and FLT3 signaling protein. Significantly, -catenin inhibition abrogated the