Great mobility group box chromosomal protein 1 (HMGB1) is a DNA-binding nuclear protein that can be released from dying cells and activated myeloid cells. also partially prevented joint destruction, as exhibited by histological examination. The beneficial antiarthritic effects by the anti-HMGB1 mAb in two diverse models of arthritis represent additional proof-of-concept, indicating that HMGB1 may… Continue reading Great mobility group box chromosomal protein 1 (HMGB1) is a DNA-binding