The gain of function mutation is very frequently found in myeloproliferative neoplasms (MPNs) and is strongly implicated in pathogenesis of these and other hematological malignancies. BCR/ABL. Consistently, the Src family kinase Lyn was constitutively activated with phosphorylation of Y396 in the AMG 548 activation loop, which was inhibited by dasatinib but not by JakI-1. Further… Continue reading The gain of function mutation is very frequently found in myeloproliferative