Background Suicide by adolescents and young adults is a major public health concern, and repetition of self-harm is an important risk element for future suicide efforts. no exit and no apparent way to reach the other. Revenge can bridge this space and thus transforms personal stress into a relational matter. This powerful feelings has been neglected by both clinicians and experts. Intro Adolescent suicide is definitely a major general public health concern in all western countries. Epidemiological data display that it is one of the three leading causes of death worldwide among those more youthful than 25 years [1], [2]. A more statistically widespread trend is definitely attempted suicide: its prevalence is about 7.8% in the United States [2] and 10.5% in Europe [3]. The highest attempted suicide rate is recorded among those aged 15C24 Trichostatin-A years, and their attempted/completed suicide ratio is definitely estimated to be Trichostatin-A between 501 and 1001 [4]. The prevention of suicidal behavior is definitely consequently a primary interpersonal and medical concern throughout the world [1], [5]. Nonetheless, despite a large number of study and prevention programs, the attempted suicide rate among youth is increasing [6], and secondary prevention interventions have thus far accomplished limited results [7], [8]. The numerous studies, carried out from multiple perspectives (including mental, psychiatric, and sociological), display that probably one of the most important risk factors for attempted suicide is usually a previous attempt [9]C[11]. According to a recent English study, repetition of self-harm occurs in about 27% of adolescents, and the four major risk factors for repetition are age, prior psychiatric treatment, self-cutting, and previous self-harm. This study also found that youths who sought care at a hospital for self-harm are 10 occasions more likely to die by suicide than would be expected Trichostatin-A in this age group [12]. Although an understanding of the adolescent perspective is essential in preventing the relapse of suicidal actions, the subjective experience of those directly involved in suicidal acts has not been sufficiently explored [13]. Qualitative methods are particularly suited to investigating participants’ viewpoints, their lived experiences, and their interior worlds [14], [15]. Nevertheless, qualitative research in adolescent suicidology is usually rare [16]. To our knowledge, only two qualitative studies [17], [18] have directly resolved the problem of relapse of suicidal or self-harming behavior among Sirt6 youth. In particular, one of them showed that current services respond inadequately to self-harming behaviors among young people and struggle to deal with the needs this population experiences [18]. The aim of this qualitative study is usually to explore the perspective of adolescents (for clarity’s sake, we refer to our participants as adolescents) who have directly engaged in suicidal acts (in either single or repeated suicide attempts). Exploring the factors related to their success or failure in overcoming and moving beyond the suicidal period might provide clinicians with important insights useful in caring for young people involved in suicidal behavior, especially in a perspective of preventing repetition. Methods Participants and Setting Participants received complete written information about the scope of the research, the identity and affiliation of the researchers, the possibility Trichostatin-A of withdrawing from the study at any point, confidentiality, and all other information required in accordance with Italian guidelines for psychological research and with the Helsinki Declaration, as revised in 1989. Participants (and their parents, for minors) provided written consent. This research received approval from the institutional review boards of the three hospitals involved: Santa Giuliana Hospital, Verona; Este Hospital, Padua; Monselice Hospital, Padua. These were two local general hospitals (with inpatient and outpatient adolescent psychiatric departments) and one psychiatric hospital in northeastern Italy. Physicians or psychologists at these hospitals were contacted and asked if they had patients who might be appropriate subjects for a study of adolescent suicide attempts. Subjects were eligible only if they had attempted suicide during adolescence or in the postadolescent period and were aged 15 to 25 years aged at the time of the interview. Eligible.